Tethering Small Molecules to a Phage Display Library: Discovery of a Selective Bivalent Inhibitor of Protein Kinase A Supporting Information
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چکیده
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Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A.
There is much current interest in developing fragment-based strategies for targeting protein surfaces and active sites.1 Toward this goal, we describe a new fragment-based bivalent ligand selection methodology that allows for the discovery of protein surface-targeted cyclic peptides that are steered by an active site binding small-molecule ligand (Figure 1). This approach allows for coupling hi...
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